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KMID : 0981820090290050390
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Korean Journal of Laboratory Medicine
2009 Volume.29 No. 5 p.390 ~ p.395
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Two Cases of Acute Myeloid Leukemia with t(16;21)(p11;q22) and TLS/FUS-ERG Fusion Transcripts
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Chang Woong-Rin
Park Il-Joong
Lee Hyun-Woo
Park Joon-Seong
Kim Hugh-Chul
Kim Hyon-Ju
Han Jae-Ho
Cho Sung-Ran
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Abstract
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Many AML-associated chromosomal abnormalities, such as t(8;21), t(15;17), inv(16), t(9;11), t(9;22) and t(6;9) are well known. The chromosomal aberration of t(16;21)(p11;q22) in AML is rare and it is known to be associated with poor prognosis, young age (median age, 22 yr), and involvement of various subtypes of the French-American-British classification. We report here 2 AML patients with t(16;21)(p11;q22), proved by conventional cytogenetics and/or reverse transcription (RT)-PCR. Erythrophagocytosis by leukemic blasts was observed in both of the cases. One patient was a 24 yr-old male with acute myelomonocytic leukemia. His karyotype was 46,XY,t(16;21)(p11;q22),del(18)(p11.2) and RT-PCR revealed the TLS/FUS-ERG fusion transcripts. Although he received allogeneic peripheral blood stem cell transplantation after the first remission, he died 9 months after the initial diagnosis due to relapse of the disease and graft-versus-host disease. The other patient was a 72 yr-old male with acute myeloid leukemia without maturation. His karyotype was 45,XY,-16,add(21)(q22) and the presence of t(16;21)(p11;q22) was detected by RT-PCR. He was transferred to another hospital with no more follow-up. We suggest that the presence of t(16;21)(p11;q22) and/or TLS/FUSERG fusion transcripts has to be considered in cases of AML with erythrophagocytosis.
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KEYWORD
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Acute myeloid leukemia, t(16, 21)(p11, q22), Erythrophagocytosis, TLS/FUS-ERG
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